High risk, high reward stuff is pretty small list tbh. A lot of frames have some form of defensive or crowd control ability. I left them off since there’s no risk to playing them.
-Ash, as mentioned. Has an ability called Bladestorm that deals a few thousand per hit and it ignores all armor and all but 1 form of damage resistance. Really powerful, but he is rather squishy. He also has an ability that teleports you to an enemy and lets you do what is called a ‘Finisher’ on them. Just an animated kill move that deals tons of damage, normally fatal. He also has a radial stun with invisibility, which is actually super good.
-Banshee is kind of the epitome of high reward. She is thin as tissue paper, but she has an ability called Sonar that acts as a massive damage multiplier. Mine sits at about an 8x damage buff because of my mods (and can stack multiple instances to increase it more). She doesn’t necessarily do high damage herself, but she enables utterly ridiculous levels of it. Higher than any other single buff in the game. Only Warframe who can hit the couple billion damage cap, actually. Her ultimate ability is also a large-radius AoE damage + permastun. She’s very powerful, but very easy to kill if you don’t watch out.
-Ivara is stealthy with her Prowl ability, which turns her invisible. She’s rather squishy, but she easily has the ability to be one of the best Warframes for melee damage. Being invisible multiplies melee damage by 8x, and she can stay invisible indefinitely if you do it right. Outside of that, she has an ability called Artemis Bow, which deals a scary amount of damage itself. One of the stronger ultimate abilities, as well, since it gets more powerful with the mods on your primary gun.
-Nova is squishy, but has 2 really good (like, top-tier good) abilities. Antimatter Drop is a slow projectile you can throw out and shoot. Can stack up to around a hundred thousand damage. It’s basically a nicely sized ‘delete’ button. Her ultimate is called Molecular Prime, which is a wave of energy that slows enemies and forces them to take 2x damage from all sources, and causes all killed enemies to explode. Combine with Antimatter Drop for a very large ‘fuck you’ zone and a whole lot of chain killing.