Just posting this to help others who have a similar problem. Built new Skylake system with the following specs:
i5 6600 CPU
8GB DDR4 RAM
R9 390 GPU
500GB velociraptor HDD
Windows 10 OS
I was having lots of CTD’s that appeared to be memory crashes, and there was lots of lagging/stuttering when playing the game. Did a little research online and found the problem. I had a custom sized page file that I had set up when configuring the SSD and changed that to system managed and the problem was resolved. This problem seems to occur most often when the game is on a separate HDD and the OS is on an SSD.
Solution: Try setting the page file size to system managed in the virtual memory setting of Windows.